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10.2174/2211352513666150318234624 34 BerheH.Kumar Cinthakunta SridharM.ZerihunM.QvitN

[DOI] [PMC free article] [PubMed] [Google Scholar] 213.Shetty S, Kusminski CM, Scherer PE

Using its potent and selective MOR agonism to study the neuroadaptive changes that occur with repeated MOR stimulation, including receptor downregulation, desensitisation, and the neurobiological basis of opioid tolerance in pre-clinical models

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Of note, APOE4 exacerbates mitochondrial dysfunction and oxidative stress within neurons, thereby amplifying neurotoxicity and contributing to neurodegenerative processes (Chen et al., 2021)